We are an independent online travel website.

Featured
Reception
Reception
Lobby sitting area
Lobby sitting area
Lobby lounge
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Private kitchen
Private kitchen
Private kitchen
Private kitchen
Living area
Living area
Living room
Living room
Bathroom
Bathroom
Bathroom
Pool
Fitness facility
Fitness facility
Spa
Property amenity
Property amenity
Property amenity
Property amenity
Property amenity
Breakfast meal
Breakfast meal
Bar (on property)
Lounge
Banquet hall
Banquet hall
Meeting facility
Meeting facility
Meeting facility
Meeting facility
Meeting facility
Meeting facility
Meeting facility
Exterior
View from property

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

4905 San Pablo Road South, Jacksonville, FL, US
4.8Excellent
Hotel amenities
Bar & Lounge
Pool
Gym
Free Wi-Fi
Pet Friendly
Laundry

See what's available

Pick your check-in and check-out dates to view rooms and rates.

About this property

Residence Inn by Marriott Jacksonville - Mayo Clinic Area is a 3-star Marriott property located in Jacksonville, Florida's Isle of Palms neighborhood. The hotel sits just 3 minutes from Mayo Clinic Florida and 9 minutes from St. Johns Town Center, making it convenient for medical visitors and business travelers. The property is also 5.2 miles from the University of North Florida and 10.3 miles from Mayport Naval Station.

The 155 air-conditioned rooms feature kitchens with refrigerators and stovetops, ideal for extended stays. Each room includes a 55-inch Smart television with cable programming, complimentary wireless internet, a desk with laptop-compatible safe, and a phone. Guest comfort ratings for the rooms average 4.8 out of 5.

Guests have access to an outdoor pool, a 24-hour fitness center, and a grocery and convenience store on-site. A complimentary buffet breakfast is served weekdays from 6:30 AM to 9:00 AM and weekends from 7:00 AM to 9:30 AM. The hotel also offers a bar and lounge, poolside bar, and concierge services. The property is smoke-free, wheelchair accessible, and permits pets up to 40 pounds with a maximum of two per room.

Check-in begins at 4:00 PM, with late check-in available until 6:00 AM. Standard check-out is 11:00 AM. The hotel maintains a 24-hour front desk, free self-parking, and meeting facilities including a ballroom and two conference rooms. Overall guest ratings stand at 4.7 out of 5 based on 376 reviews.

Location & nearby attractions

With a stay at Residence Inn By Marriott Jacksonville - Mayo Clinic Area in Jacksonville (Isle of Palms), you'll be a 1-minute drive from Mayo Clinic Florida and 9 minutes from St. Johns Town Center. This hotel is 10.3 mi (16.5 km) from Mayport Naval Station and 5.2 mi (8.4 km) from University of North Florida.
Distances are displayed to the nearest 0.1 mile and kilometer.

Mayo Clinic Florida - 0.5 km / 0.3 mi
Harbor City Municipal Golf Course - 2.7 km / 1.7 mi
Windsor Commons Shopping Center - 3.8 km / 2.4 mi
Windsor Parke Golf Club - 5.2 km / 3.2 mi
South Beach Park and Sunshine Playground - 6.5 km / 4 mi
Blue Jay Listening Room - 7.1 km / 4.4 mi
Atlantic Beach - 7.1 km / 4.4 mi
Jacksonville Beach Tennis Center - 7.1 km / 4.4 mi
Huguenot Park - 7.3 km / 4.5 mi
Pablo Plaza Shopping Center - 7.5 km / 4.6 mi
Gonzales Park - 7.8 km / 4.8 mi
Jacksonville Beach Golf Club - 7.9 km / 4.9 mi
Sleiman South Shopping Center - 8 km / 5 mi
Cradle Creek Preserve - 8 km / 5 mi
Players by the Sea - 8.2 km / 5.1 mi

The nearest airports are:
Jacksonville, FL (CRG-Jacksonville Executive at Craig) - 18.1 km / 11.2 mi
St. Augustine, FL (UST-Northeast Florida Regional) - 55.2 km / 34.3 mi
Jacksonville International Airport (JAX) - 44.3 km / 27.5 mi
Daytona Beach Intl. Airport (DAB) - 144.1 km / 89.5 mi

Rooms

Make yourself at home in one of the 155 air-conditioned rooms featuring kitchens with refrigerators and stovetops. 55-inch Smart televisions with cable programming provide entertainment, while complimentary wireless internet access keeps you connected. Conveniences include phones, as well as laptop-compatible safes and desks.

Dining

Grab a bite from the grocery/convenience store serving guests of Residence Inn By Marriott Jacksonville - Mayo Clinic Area. Relax with your favorite drink at the bar/lounge or the poolside bar. A complimentary buffet breakfast is served on weekdays from 6:30 AM to 9:00 AM and on weekends from 7:00 AM to 9:30 AM.

Amenities & features

Be sure to enjoy recreational amenities including an outdoor pool and a 24-hour fitness center. This hotel also features complimentary wireless internet access, concierge services, and wedding services.
Featured amenities include a 24-hour business center, express check-out, and complimentary newspapers in the lobby. Planning an event in Jacksonville? This hotel has 2678 square feet (249 square meters) of space consisting of conference space and 2 meeting rooms. Free self parking is available onsite.

Getting here

Sorry, no airport shuttle available.

Check-in & check-out

Check-in 4:00 PM - 6:00 AM
Check-out 11:00 AM
  • Extra-person charges may apply and vary depending on property policy
  • Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
  • Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
  • This property accepts credit cards; cash is not accepted
  • Cashless transactions are available
  • Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector, and window guards
  • If you are planning to arrive after 11:00 PM please contact the property in advance using the information on the booking confirmation. Front desk staff will greet guests on arrival at the property. Information provided by the property may be translated using automated translation tools.

Contactless check-in is available

Contactless check-out is available

Pet policy

Pets are welcome.

Fees & policies

  • You'll be asked to pay the following charges at the property. Fees may include applicable taxes: Refundable incidentals deposit: $125 per accommodation, per stay We have included all charges provided to us by the property. Pet fee: $150 per accommodation, per stay Service animals are exempt from fees The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

Know before you go

  • Only registered guests are allowed in the guestrooms.
  • The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
  • Guests can arrange to bring pets by contacting the property directly, using the contact information on the booking confirmation (surcharges apply and can be found in the Fees section).
  • Cashless payment methods are available for all transactions and guests can access their rooms with a mobile device.
  • Contactless check-in and contactless check-out are available.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Frequently asked questions

What are the check-in and check-out times at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

Check-in starts at 4:00 PM - 6:00 AM. Check-out is by 11:00 AM.

Where is Residence Inn By Marriott Jacksonville - Mayo Clinic Area located?

Residence Inn By Marriott Jacksonville - Mayo Clinic Area is located at 4905 San Pablo Road South, Jacksonville, FL, US.

What attractions are near Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

Distances are displayed to the nearest 0.1 mile and kilometer. Mayo Clinic Florida - 0.5 km / 0.3 mi Harbor City Municipal Golf Course - 2.7 km / 1.7 mi Windsor Commons Shopping Center - 3.8 km / 2.4 mi Windsor Parke Golf Club - 5.2 km / 3.2 mi South Beach Park and Sunshine Playground - 6.5 km / 4 mi Blue Jay Listening Room - 7.1 km / 4.4 mi Atlantic Beach - 7.1 km / 4.4 mi Jacksonville Beach Tennis Center - 7.1 km / 4.4 mi Huguenot Park - 7.3 km / 4.5 mi Pablo Plaza Shopping Center - 7.5 km / 4.6 mi Gonzales Park - 7.8 km / 4.8 mi Jacksonville Beach Golf Club - 7.9 km / 4.9 mi Sleiman South Shopping Center - 8 km / 5 mi Cradle Creek Preserve - 8 km / 5 mi Players by the Sea - 8.2 km / 5.1 mi The nearest airports are: Jacksonville, FL (CRG-Jacksonville Executive at Craig) - 18.1 km / 11.2 mi St. Augustine, FL (UST-Northeast Florida Regional) - 55.2 km / 34.3 mi Jacksonville International Airport (JAX) - 44.3 km / 27.5 mi Daytona Beach Intl. Airport (DAB) - 144.1 km / 89.5 mi

How do I get to Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

Sorry, no airport shuttle available.

What dining options are available at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

Grab a bite from the grocery/convenience store serving guests of Residence Inn By Marriott Jacksonville - Mayo Clinic Area. Relax with your favorite drink at the bar/lounge or the poolside bar. A complimentary buffet breakfast is served on weekdays from 6:30 AM to 9:00 AM and on weekends from 7:00 AM to 9:30 AM.

What amenities does Residence Inn By Marriott Jacksonville - Mayo Clinic Area offer?

Residence Inn By Marriott Jacksonville - Mayo Clinic Area features amenities such as Bar & Lounge, Pool, Gym, Free Wi-Fi, Pet Friendly, Laundry.

What are the rooms like at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

Make yourself at home in one of the 155 air-conditioned rooms featuring kitchens with refrigerators and stovetops. 55-inch Smart televisions with cable programming provide entertainment, while complimentary wireless internet access keeps you connected. Conveniences include phones, as well as laptop-compatible safes and desks.

Is Residence Inn By Marriott Jacksonville - Mayo Clinic Area pet-friendly?

Yes, Residence Inn By Marriott Jacksonville - Mayo Clinic Area is pet-friendly.

What fees should I know about at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

You'll be asked to pay the following charges at the property. Fees may include applicable taxes: Refundable incidentals deposit: $125 per accommodation, per stay We have included all charges provided to us by the property. Pet fee: $150 per accommodation, per stay Service animals are exempt from fees The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

What should I know before staying at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

Only registered guests are allowed in the guestrooms. The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation. Guests can arrange to bring pets by contacting the property directly, using the contact information on the booking confirmation (surcharges apply and can be found in the Fees section). Cashless payment methods are available for all transactions and guests can access their rooms with a mobile device. Contactless check-in and contactless check-out are available. This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).