We are an independent online travel website.

Featured
Lobby
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Room
Bathroom
Pool
Fitness facility
Fitness facility
Fitness facility
Fitness facility
Spa
Spa
Spa
Spa
Spa
Spa
Billiards
Dining
Breakfast area
Breakfast area
Restaurant
Restaurant
Restaurant
Restaurant
Restaurant
Restaurant
Restaurant
Restaurant
Restaurant
Restaurant
Restaurant
Restaurant
Restaurant
Restaurant
Restaurant
Cafe
Bar (on property)
Interior
Interior
Meeting facility
Meeting facility
Meeting facility
Meeting facility
Meeting facility
Meeting facility
Business center
Exterior
Exterior
Exterior

21C Museum Hotel St Louis

1528 Locust street, St. Louis, MO, US
4.5Excellent
Hotel amenities
Bar & Lounge
Pool
Gym
Restaurant
Spa
Free Wi-Fi

See what's available

Pick your check-in and check-out dates to view rooms and rates.

About this property

21C Museum Hotel St. Louis is a 4.5-star Accor property located in the heart of St. Louis, within a 10-minute walk of St. Louis Union Station and City Museum. The hotel comprises 104 guest rooms and sits 0.4 miles from Enterprise Center, making it convenient for business and leisure travelers alike.

Each of the 104 air-conditioned rooms is equipped with an espresso maker, flat-screen television, and complimentary wireless internet access. Cable programming is available for entertainment. Bathrooms include complimentary toiletries and hair dryers, while rooms feature phones, safes, and desks for added convenience. The property has earned a guest comfort rating of 4.7 out of 5.

The hotel operates one on-site restaurant serving full meals, alongside a coffee shop and café for lighter options. A bar and lounge provide drinks and evening entertainment. Room service is available during limited hours. Cooked-to-order breakfasts are served daily from 6:30 AM to 1:00 PM for an additional fee.

Recreational facilities include an indoor swimming pool, steam room, and fitness center. The property also offers complimentary wireless internet access, concierge services, a banquet hall for events, a business center, and dry cleaning and laundry services. Spa services are available on site. A 24-hour front desk and luggage storage are provided for guest convenience.

The property is smoke-free and wheelchair accessible throughout, with accessible public restrooms, registration desk, spa facilities, pool, fitness center, and on-site restaurant. Visual alarms in hallways and handrails in stairways support guest safety. Wheelchairs are available on site. The hotel maintains environmentally conscious practices, including the elimination of single-use plastics and use of reusable cups and tableware. Dogs and service animals are welcome.

Check-in begins at 4:00 PM and extends to 11:00 AM; check-out is at 11:00 AM. The property has been recognized as Green Key Global certified and is LGBTQIA+ friendly. With an overall guest rating of 4.5 out of 5 across 1,112 reviews, 21C Museum Hotel St. Louis offers reliable hospitality in downtown St. Louis.

Location & nearby attractions

A stay at 21C Museum Hotel St Louis places you in the heart of St. Louis, within a 10-minute walk of St. Louis Union Station and City Museum. This luxury hotel is 0.4 mi (0.7 km) from Enterprise Center and 0.7 mi (1.1 km) from America's Center Convention Complex.
Distances are displayed to the nearest 0.1 mile and kilometer.

Washington Avenue Historic District - 0.2 km / 0.1 mi
City Museum - 0.4 km / 0.3 mi
Stifel Theatre - 0.5 km / 0.3 mi
Enterprise Center - 0.7 km / 0.4 mi
Energizer Park - 0.7 km / 0.4 mi
St. Louis Union Station - 0.7 km / 0.4 mi
St. Louis City Hall - 0.7 km / 0.4 mi
St. Louis Aquarium at Union Station - 0.9 km / 0.5 mi
St. Louis Union Station Mini Golf - 0.9 km / 0.6 mi
The St. Louis Wheel - 1.1 km / 0.7 mi
The Hawthorn - 1.1 km / 0.7 mi
America's Center Convention Complex - 1.1 km / 0.7 mi
National Blues Museum - 1.3 km / 0.8 mi
Kiener Plaza - 1.3 km / 0.8 mi
Dome at America’s Center - 1.4 km / 0.9 mi

The nearest airports are:
St. Louis Lambert Intl. Airport (STL) - 29.6 km / 18.4 mi
Belleville, IL (BLV-MidAmerica-St. Louis) - 41.6 km / 25.9 mi
St. Louis, MO (SUS-Spirit of St. Louis) - 41.6 km / 25.8 mi

Rooms

Make yourself at home in one of the 104 air-conditioned rooms featuring espresso makers and flat-screen televisions. Complimentary wireless internet access keeps you connected, and cable programming is available for your entertainment. Bathrooms have complimentary toiletries and hair dryers. Conveniences include phones, as well as safes and desks.

Dining

Enjoy a meal at the restaurant or snacks in the coffee shop/cafe. The hotel also offers room service (during limited hours). Wrap up your day with a drink at the bar/lounge. Cooked-to-order breakfasts are available daily from 6:30 AM to 1:00 PM for a fee.

Amenities & features

Don't miss out on the many recreational opportunities, including an indoor pool, a steam room, and a fitness center. Additional amenities at this hotel include complimentary wireless internet access, concierge services, and a banquet hall.
Featured amenities include a business center, dry cleaning/laundry services, and a 24-hour front desk.

Getting here

Sorry, no airport shuttle available.

Check-in & check-out

Check-in 4:00 PM - 11:00 AM
Check-out 11:00 AM
  • Extra-person charges may apply and vary depending on property policy
  • Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
  • Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
  • This property accepts credit cards; cash is not accepted
  • Safety features at this property include a fire extinguisher, a smoke detector, and outdoor lighting
  • Front desk staff will greet guests on arrival at the property. Information provided by the property may be translated using automated translation tools.

Pet policy

Pets are welcome.

Fees & policies

  • You'll be asked to pay the following charges at the property. Fees may include applicable taxes: Service fee: $5 per accommodation, per stay We have included all charges provided to us by the property. Fee for cooked-to-order breakfast: approximately $10 to 25 per person Valet parking fee: $55 per day (in/out privileges) Pet fee: $100 per accommodation, per stay Service animals are exempt from fees The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

Know before you go

  • Reservations are required for massage services. Reservations can be made by contacting the hotel prior to arrival, using the contact information on the booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Frequently asked questions

What are the check-in and check-out times at 21C Museum Hotel St Louis?

Check-in starts at 4:00 PM - 11:00 AM. Check-out is by 11:00 AM.

Where is 21C Museum Hotel St Louis located?

21C Museum Hotel St Louis is located at 1528 Locust street, St. Louis, MO, US.

What attractions are near 21C Museum Hotel St Louis?

Distances are displayed to the nearest 0.1 mile and kilometer. Washington Avenue Historic District - 0.2 km / 0.1 mi City Museum - 0.4 km / 0.3 mi Stifel Theatre - 0.5 km / 0.3 mi Enterprise Center - 0.7 km / 0.4 mi Energizer Park - 0.7 km / 0.4 mi St. Louis Union Station - 0.7 km / 0.4 mi St. Louis City Hall - 0.7 km / 0.4 mi St. Louis Aquarium at Union Station - 0.9 km / 0.5 mi St. Louis Union Station Mini Golf - 0.9 km / 0.6 mi The St. Louis Wheel - 1.1 km / 0.7 mi The Hawthorn - 1.1 km / 0.7 mi America's Center Convention Complex - 1.1 km / 0.7 mi National Blues Museum - 1.3 km / 0.8 mi Kiener Plaza - 1.3 km / 0.8 mi Dome at America’s Center - 1.4 km / 0.9 mi The nearest airports are: St. Louis Lambert Intl. Airport (STL) - 29.6 km / 18.4 mi Belleville, IL (BLV-MidAmerica-St. Louis) - 41.6 km / 25.9 mi St. Louis, MO (SUS-Spirit of St. Louis) - 41.6 km / 25.8 mi

How do I get to 21C Museum Hotel St Louis?

Sorry, no airport shuttle available.

What dining options are available at 21C Museum Hotel St Louis?

Enjoy a meal at the restaurant or snacks in the coffee shop/cafe. The hotel also offers room service (during limited hours). Wrap up your day with a drink at the bar/lounge. Cooked-to-order breakfasts are available daily from 6:30 AM to 1:00 PM for a fee.

What amenities does 21C Museum Hotel St Louis offer?

21C Museum Hotel St Louis features amenities such as Bar & Lounge, Pool, Gym, Restaurant, Spa, Free Wi-Fi.

What are the rooms like at 21C Museum Hotel St Louis?

Make yourself at home in one of the 104 air-conditioned rooms featuring espresso makers and flat-screen televisions. Complimentary wireless internet access keeps you connected, and cable programming is available for your entertainment. Bathrooms have complimentary toiletries and hair dryers. Conveniences include phones, as well as safes and desks.

Is 21C Museum Hotel St Louis pet-friendly?

Yes, 21C Museum Hotel St Louis is pet-friendly.

What fees should I know about at 21C Museum Hotel St Louis?

You'll be asked to pay the following charges at the property. Fees may include applicable taxes: Service fee: $5 per accommodation, per stay We have included all charges provided to us by the property. Fee for cooked-to-order breakfast: approximately $10 to 25 per person Valet parking fee: $55 per day (in/out privileges) Pet fee: $100 per accommodation, per stay Service animals are exempt from fees The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

What should I know before staying at 21C Museum Hotel St Louis?

Reservations are required for massage services. Reservations can be made by contacting the hotel prior to arrival, using the contact information on the booking confirmation. This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).